Dissipated work and total entropy production. Stochastic thermodynamics is relevant for small systems

References:

"Non-equilibrium fluctuations in small systems: From physics to biology", 2007, F. Ritort, arXiv:0705.0455v1

"The Non-equilibrium Thermodynamics of Small Systems", 2005, C. Bustamante, J Liphardt, F. Ritort, Physics Today 58, 43-48